Controlled Substance Reporting System

NC HealthConnex is working with the N.C. Department of Health and Human Services and Appriss Health to build a single sign-on to the NC HealthConnex clinical portal utilizing the Appriss interface.

This integration will create an additional pathway for providers to access the state’s prescription-drug monitoring program, Controlled Substances Reporting System (CSRS), and help combat the opioid epidemic in North Carolina.

Combatting Opioid Misuse

Per the Strengthen Opioid Misuse Prevention (STOP) Act of 2017 (NCSL 2017-74), health care providers in North Carolina who prescribe controlled substances must access a patient report from the CSRS to verify a patient’s prescription-fill history of controlled substances prior to writing prescriptions for targeted controlled substances.

This Phase 1 integration allows the end user already accessing the longitudinal NC HealthConnex clinical portal to view the CSRS report, along with the risk scores, without leaving the HIE portal. This simple process does not require the user to log in to another system outside of the HIE portal and is integrated into the portal workflow. When the provider views the report, the system automatically records the access into the audit logs, providing support for CSRS use requirements in the STOP Act. A pilot has begun with a select user group. Additional users who have completed the access request process began onboarding at the end of August 2020.

Additional means to deliver the integration directly into NC HealthConnex participants’ workflow are also being explored for a Phase 2 implementation, which will be especially beneficial for participants whose electronic health records are not compatible with the Appriss interface.

To use NC HealthConnex to meet the STOP Act Requirement:

  • Providers should visit and select NC HealthConnex in the dropdown menu as their preference for connection within the integration request form. Note: Providers need to be full participants of NC HealthConnex to choose this option. Complete the terms and conditions agreement, which will be sent by N.C. Department of Health and Human Services (NCDHHS) to you via email within 24-48 hours. 
  • There is no fee for this option.
  • Submit your integration request via the "Integration request form" link on the page noted above.
  • Ensure that you identify a primary contact (the person leading the project within your health care organization), as well as a contact for your software vendor.
  • You must first complete all documents before NCDHHS will review your request.
  • Wait for your request to be approved for integration with NC HealthConnex by NCDHHS.
  • Once approved by NCDHHS, NC HIEA will be notified and will communicate with the primary contact listed on the integration request form.
  • All providers will also need to be registered for the NC CSRS website, if you are not registered you can do so by going to, and clicking on "Create an account" and following the instructions. Note: Provider information used to register with NC CSRS website will have to match the provider's information in NC HealthConnex. 

For additional information on NC CSRS, please visit